San Isidro Beach is generally safe for families and swimming, offering a calm, relaxed environment typical of Masbate's coastal areas. The sandy beach typically has gentle waters suitable for children, though parental supervision is always essential. As a less-developed, hidden beach, formal lifeguard services may not be available, so visitors should exercise personal caution. Check local weather and sea conditions before swimming, and avoid the water during rough weather or monsoon periods. The family-friendly atmosphere and quieter setting make it appealing for those seeking a peaceful beach experience away from crowds.

San Isidro Beach can be visited year-round, making it convenient for budget-conscious travelers with flexible schedules. The dry season from November to May provides the most reliable weather with sunny days and calm seas, ideal for swimming and beach activities. However, the beach remains accessible during other months, though June to October may bring occasional rain showers. Since it's categorized as a secondary beach in Mobo, it tends to be less crowded regardless of season. For the best sunset views, plan to stay through late afternoon regardless of when you visit.